"Contrary to the perception that recent variants have become successively milder, Omicron BA.2 was associated with reporting more symptoms, with greater disruption to daily activities [than BA.1]"
https://twitter.com/EricTopol/status/1529097010741096457?s=20&t=PLg8ieQmfFHBhVPjJKfK8g
Substantial immune escape of BA.4/BA.5 variants compared with BA.1 and BA.2, less neutralization by triple-vaccinated serum, antigenic distance and structure-function characterized
https://twitter.com/EricTopol/status/1529088073945911299?s=20&t=PLg8ieQmfFHBhVPjJKfK8g
"The observation...suggests there remains plenty of antigenic space for #SARSCoVB2 to explore and the capacity for recombination, which has so far not been
observed to have breakpoints within the major antigenic sites, could generate more radical antigenic shift."