"BA.4/BA.5 are antigenically distinct from previous Omicron variants, particularly BA.1, and are still at a substantial distance from the closely related BA.2." Breakthrough infections help -> pan-Omicron nAbs
https://twitter.com/EricTopol/status/1529607449665232896?s=20&t=PLg8ieQmfFHBhVPjJKfK8g